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Southern Cheesy Chicken Spaghetti Casserole is a comforting baked dish featuring spaghetti, chicken, a creamy cheese sauce, and a golden-brown topping, perfect for a family dinner.
Isabella

Easy Southern Cheesy Chicken Spaghetti Casserole

This Southern Cheesy Chicken Spaghetti Casserole is a comforting and satisfying dish packed with cheesy goodness and tender chicken. It's an easy-to-make, creamy, and flavorful casserole perfect for weeknight dinners and guaranteed to become a family favorite.
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Prep Time 25 minutes
Cook Time 30 minutes
Total Time 55 minutes
Servings: 6
Course: Main Course
Cuisine: American
Calories: 650
Ingredients Equipment Method Notes

Ingredients
  

  • 1.5 lbs boneless, skinless chicken breasts
  • 1 tbsp olive oil
  • 1 tsp salt
  • 1/2 tsp black pepper
  • 1/2 tsp garlic powder
  • 1 lb spaghetti
  • 8 oz cream cheese, softened
  • 1 cup sour cream
  • 1/2 cup milk
  • 1/2 cup chopped onion
  • 1/4 cup chopped green bell pepper
  • 2 cups shredded cheddar cheese, divided
  • 1/2 cup grated Parmesan cheese
  • Salt to taste
  • Pepper to taste

Equipment

  • Large Pot
  • Colander
  • large skillet
  • Large bowl
  • 9x13 inch baking dish
  • measuring cups and spoons
  • mixing spoon
  • Fork (for shredding chicken)
  • Oven

Method
 

  1. Cook the spaghetti according to package directions until al dente. Drain well and set aside.
  2. If using raw chicken, cook the chicken. You can poach, bake, or use leftover cooked chicken. Shred the cooked chicken into bite-sized pieces.
  3. Preheat oven to 350°F (175°C).
  4. In a large skillet, heat the olive oil over medium heat. Add the chopped onion and green bell pepper and cook until softened, about 5 minutes.
  5. In a large bowl, combine the cooked spaghetti, sautéed vegetables, shredded chicken, cream of mushroom soup, cream of chicken soup, diced tomatoes and green chilies, cream cheese, sour cream, milk, 1 1/2 cups of the cheddar cheese, and Parmesan cheese.
  6. Season with salt and pepper to taste. Mix well until everything is evenly combined.
  7. Pour the spaghetti mixture into a lightly greased 9x13 inch baking dish.
  8. Sprinkle the remaining 1/2 cup of cheddar cheese over the top.
  9. Bake for 25-30 minutes, or until the casserole is bubbly and the cheese is melted and lightly golden brown.
  10. Let stand for 5-10 minutes before serving.

Notes

For a spicier dish, add a pinch of red pepper flakes or use hot diced tomatoes and green chilies. You can substitute different cheeses like Monterey Jack or mozzarella. Add sauteed mushrooms, zucchini, or spinach for extra vegetables. Leftover casserole can be stored in an airtight container in the refrigerator for up to 3-4 days. Reheat in a preheated oven at 350°F (175°C) or microwave individual portions.