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Easy Southern Chicken Spaghetti Casserole features creamy spaghetti, tender chicken, and melted cheese, perfect for a comforting family meal.
Lady Maria

Ultimate Chicken Spaghetti Casserole

This Ultimate Chicken Spaghetti Casserole is a comforting and easy-to-make dish that's perfect for weeknight dinners or potlucks. It features tender chicken, perfectly cooked spaghetti, and a creamy, flavorful cheese sauce, all baked to golden perfection.
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Prep Time 20 minutes
Cook Time 25 minutes
Total Time 45 minutes
Servings: 6
Course: Main Course
Cuisine: Southern
Calories: 450
Ingredients Equipment Method Notes

Ingredients
  

  • 1 pound spaghetti
  • 1 tablespoon olive oil
  • 1/2 cup chopped onion
  • 1/2 cup chopped green bell pepper
  • 1/2 cup chopped red bell pepper
  • 2 cloves garlic, minced
  • 2 cups cooked chicken, shredded
  • 8 ounces Velveeta cheese, cubed
  • 1 cup chicken broth
  • 1/2 teaspoon garlic powder
  • 1/4 teaspoon black pepper
  • 1/4 teaspoon salt
  • 1 cup shredded cheddar cheese
  • Optional: 1/2 cup crushed buttery crackers or breadcrumbs

Equipment

  • 9x13 inch baking dish
  • Large Pot
  • Colander
  • large skillet
  • Large bowl
  • Microwave-safe bowl or saucepan
  • measuring cups and spoons
  • Stirring spoons
  • Oven

Method
 

  1. Preheat oven to 350°F (175°C). Grease a 9x13 inch baking dish.
  2. Cook spaghetti according to package directions. Drain well and set aside.
  3. While spaghetti is cooking, heat olive oil in a large skillet over medium heat.
  4. Add onion and bell peppers and cook until softened, about 5-7 minutes.
  5. Add minced garlic and cook for another minute, until fragrant.
  6. In a large bowl, combine cream of mushroom soup, cream of chicken soup, diced tomatoes and green chilies (undrained), Velveeta cheese, chicken broth, garlic powder, salt, and pepper.
  7. Microwave the mixture for 2-3 minutes, stirring every minute, until the Velveeta cheese is melted and the sauce is smooth. Alternatively, melt on the stovetop over low heat, stirring constantly.
  8. Add the cooked spaghetti, shredded chicken, and sautéed vegetables to the creamy cheese sauce. Mix well to combine.
  9. Pour the mixture into the prepared baking dish.
  10. Sprinkle the top with shredded cheddar cheese and, if desired, crushed buttery crackers or breadcrumbs.
  11. Bake in the preheated oven for 20-25 minutes, or until the casserole is bubbly and the cheese is melted and golden brown.
  12. Let the casserole cool for a few minutes before serving.

Notes

For a richer flavor, use homemade chicken broth. To spice things up, add a pinch of cayenne pepper or a dash of hot sauce to the sauce. This casserole can be assembled ahead of time and stored in the refrigerator for up to 24 hours; add a few extra minutes to the baking time. Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the microwave or oven until warmed through.